True social isolation over years and decades can be a chronic condition affecting all aspects of a person's existence. Social isolation can lead to feelings of loneliness, fear of others, or negative self-esteem. Lack of consistent human contact can also cause conflict with (peripheral) friends. The socially isolated person may occasionally talk to or cause problems with family members.
The magnitude of risk associated with social isolation is comparable with that of cigarette smoking and other major biomedical and psychosocial risk factors. However, our understanding of how and why social isolation is risky for health – or conversely – how and why social ties and relationships are protective of health, still remains quite limited.
James S. House, Psychosomatic Medicine, 2001, Issue 2, Volume 63, pages 273–274[3]
In the case of mood-related isolation, the individual may isolate during a depressive episode only to 'surface' when their mood improves. The individual may attempt to justify their reclusive or isolating behavior as enjoyable or comfortable. There can be an inner realization on the part of the individual that there is something wrong with their isolating responses which can lead to heightened anxiety.[2] Relationships can be a struggle, as the individual may reconnect with others during a healthier mood only to return to an isolated state during a subsequent low or depressed